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Two clicks install ». Download Close. Their studies used no control groups and called for bed rest along with DES. Looking back, it seems likely the bed rest, and not the drug prevented miscarriage. But at the time drug makers were enthusiastic about DES. It was cheap and easy to produce so every pill prescribed made money for them.
Of note is that DES was never patented, so it was produced by many drug companies and marketed using hundreds of brand names. One of the major U. Lilly was proud of its sales force and even ran advertisements touting it in medical journals. This fascinating ad is from the s and was provided by the American Institute of the History of Pharmacy. In those days, with no direct to consumer marketing, drug companies heavily marketed their products to doctors.
DES is an excellent example of how well that worked in convincing providers to prescribe specific drugs. In the late s and early s cases of the specific rare cancer, clear cell adenocarcinoma of the vaginal and cervix, were being diagnosed in young women.
It took a persistent DES Mother to unravel the mystery. It is no longer used due to the incidence of certain vaginal cancers in the daughters of women so treated. Published by Houghton Mifflin Company. Short for diethylstilbestrol. A synthetic nonsteroidal substance having estrogenic properties and prescribed between and to pregnant women with a history of miscarriage and other problems of pregnancy. It is no longer used due to the incidence of certain vaginal cancers and other disorders in the daughters of women so treated.
Men whose mothers took DES while pregnant should inform their health care provider of their exposure and be examined periodically. Although the risk of developing testicular cancer among DES-exposed sons is unclear, males with undescended or unusually small testicles have an increased risk of testicular cancer whether or not they were exposed to DES.
Each woman should discuss this question with her health care provider. There is no evidence that hormone replacement therapy is unsafe for DES daughters. However, some clinicians believe that DES daughters should avoid these medications because they contain estrogen Participants were initially drawn from eight different medical centers and consisted of five individual cohorts of people. For the study findings to be valid, enrollment is limited to participants who have been part of existing cohorts.
Researchers continue to study DES daughters as they move through their menopausal years. In a pilot study, postmenopausal DES daughters had altered estrogen metabolism compared with unexposed women, suggesting that prenatal exposure to this endocrine disruptor may influence estrogen metabolism many years later The cancer risks for exposed sons are also being studied to determine whether they differ from those for unexposed men.
In addition, researchers are studying possible health effects on the DES grandchildren NIEHS researchers developed a rodent model of prenatal DES exposure that has been useful in replicating and predicting adverse health effects. This experimental model has been used worldwide to study mechanisms involved in DES-related toxicity and the adverse effects of less potent environmental estrogens. Staff members also answer questions from the public.
It provides information and resources about DES research and health screening guidelines. Menu Contact Dictionary Search. Understanding Cancer. What Is Cancer? Cancer Statistics. Cancer Disparities. Cancer Causes and Prevention. Risk Factors. Cancer Prevention Overview. Cancer Screening Overview. Screening Tests. Diagnosis and Staging. Questions to Ask about Your Diagnosis. Types of Cancer Treatment. Side Effects of Cancer Treatment. Clinical Trials Information. A to Z List of Cancer Drugs.
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